The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help

Germinal center (GC) B cells cycle between two states, the light zone (LZ) and the dark zone (DZ), and in the latter they proliferate and hypermutate their immunoglobulin genes. How this functional transition takes place is still controversial. In this study, we demonstrate that ablation of Foxo1 af...

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Publicado en:J Exp Med
Autores principales: Inoue, Takeshi, Shinnakasu, Ryo, Ise, Wataru, Kawai, Chie, Egawa, Takeshi, Kurosaki, Tomohiro
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2017
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379976/
https://ncbi.nlm.nih.gov/pubmed/28351982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161263
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