The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help

Germinal center (GC) B cells cycle between two states, the light zone (LZ) and the dark zone (DZ), and in the latter they proliferate and hypermutate their immunoglobulin genes. How this functional transition takes place is still controversial. In this study, we demonstrate that ablation of Foxo1 af...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Inoue, Takeshi, Shinnakasu, Ryo, Ise, Wataru, Kawai, Chie, Egawa, Takeshi, Kurosaki, Tomohiro
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379976/
https://ncbi.nlm.nih.gov/pubmed/28351982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161263
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