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Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel
Desensitization in pentameric ligand-gated ion channels plays an important role in regulating neuronal excitability. Here, we show that docosahexaenoic acid (DHA), a key ω−3 polyunsaturated fatty acid in synaptic membranes, enhances the agonist-induced transition to the desensitized state in the pro...
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| Gepubliceerd in: | eLife |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
eLife Sciences Publications, Ltd
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5378477/ https://ncbi.nlm.nih.gov/pubmed/28262093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23886 |
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