MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype

Rationale: Pulmonary arterial hypertension (PAH) is an obstructive vasculopathy characterized by excessive pulmonary artery smooth muscle cell (PASMC) proliferation, migration, and apoptosis resistance. This cancer-like phenotype is promoted by increased cytosolic calcium ([Ca(2+)](cyto)), aerobic g...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Hong, Zhigang, Chen, Kuang-Hueih, DasGupta, Asish, Potus, Francois, Dunham-Snary, Kimberly, Bonnet, Sebastien, Tian, Lian, Fu, Jennifer, Breuils-Bonnet, Sandra, Provencher, Steeve, Wu, Danchen, Mewburn, Jeffrey, Ormiston, Mark L., Archer, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378421/
https://ncbi.nlm.nih.gov/pubmed/27648837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201604-0814OC
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