Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APC(Min/+) Mice

Chronic intestinal inflammation accompanies familial adenomatous polyposis (FAP) and is a major risk factor for colorectal cancer in patients with this disease, but the cause of such inflammation is unknown. Since retinoic acid (RA) plays a critical role in maintaining immune homeostasis in the inte...

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Publié dans:Cancer Immunol Res
Auteurs principaux: Penny, Hweixian Leong, Prestwood, Tyler R., Bhattacharya, Nupur, Sun, Fionna, Kenkel, Justin A., Davidson, Matthew G., Shen, Lei, Zuniga, Luis A., Seeley, E. Scott, Pai, Reetesh, Choi, Okmi, Tolentino, Lorna, Wang, Jinshan, Napoli, Joseph L., Engleman, Edgar G.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378314/
https://ncbi.nlm.nih.gov/pubmed/27638841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0038
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