Normalizing microbiota-induced retinoic acid deficiency stimulates protective CD8(+) T-cell-mediated immunity in colorectal cancer

Although all-trans retinoic acid (atRA) is a key regulator of intestinal immunity, its role in colorectal cancer (CRC) is unknown. We found that mice with colitis-associated CRC had a marked deficiency in colonic atRA due to alterations in atRA metabolism mediated by microbiota-induced intestinal in...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Immunity
Asıl Yazarlar: Bhattacharya, Nupur, Yuan, Robert, Prestwood, Tyler R., Penny, Hweixian Leong, DiMaio, Michael A., Reticker-Flynn, Nathan E., Krois, Charles R., Kenkel, Justin A., Pham, Tho D., Carmi, Yaron, Tolentino, Lorna, Choi, Okmi, Hulett, Reyna, Wang, Jinshan, Winer, Daniel, Napoli, Joseph L., Engleman, Edgar G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132405/
https://ncbi.nlm.nih.gov/pubmed/27590114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.08.008
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