Normalizing microbiota-induced retinoic acid deficiency stimulates protective CD8(+) T-cell-mediated immunity in colorectal cancer

Although all-trans retinoic acid (atRA) is a key regulator of intestinal immunity, its role in colorectal cancer (CRC) is unknown. We found that mice with colitis-associated CRC had a marked deficiency in colonic atRA due to alterations in atRA metabolism mediated by microbiota-induced intestinal in...

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Publicat a:Immunity
Autors principals: Bhattacharya, Nupur, Yuan, Robert, Prestwood, Tyler R., Penny, Hweixian Leong, DiMaio, Michael A., Reticker-Flynn, Nathan E., Krois, Charles R., Kenkel, Justin A., Pham, Tho D., Carmi, Yaron, Tolentino, Lorna, Choi, Okmi, Hulett, Reyna, Wang, Jinshan, Winer, Daniel, Napoli, Joseph L., Engleman, Edgar G.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132405/
https://ncbi.nlm.nih.gov/pubmed/27590114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.08.008
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