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An adaptive design for updating the threshold value of a continuous biomarker
Potential predictive biomarkers are often measured on a continuous scale, but in practice, a threshold value to divide the patient population into biomarker ‘positive’ and ‘negative’ is desirable. Early phase clinical trials are increasingly using biomarkers for patient selection, but at this stage,...
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| Publicado no: | Stat Med |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5378309/ https://ncbi.nlm.nih.gov/pubmed/27417407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7042 |
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