A Bayesian adaptive design for biomarker trials with linked treatments

BACKGROUND: Response to treatments is highly heterogeneous in cancer. Increased availability of biomarkers and targeted treatments has led to the need for trial designs that efficiently test new treatments in biomarker-stratified patient subgroups. METHODS: We propose a novel Bayesian adaptive rando...

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Udgivet i:Br J Cancer
Main Authors: Wason, James M S, Abraham, Jean E, Baird, Richard D, Gournaris, Ioannis, Vallier, Anne-Laure, Brenton, James D, Earl, Helena M, Mander, Adrian P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Clinical Study
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4559835/
https://ncbi.nlm.nih.gov/pubmed/26263479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.278
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