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Optimal multistage designs for randomised clinical trials with continuous outcomes
Multistage designs allow considerable reductions in the expected sample size of a trial. When stopping for futility or efficacy is allowed at each stage, the expected sample size under different possible true treatment effects (δ) is of interest. The δ-minimax design is the one for which the maximum...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Blackwell Publishing Ltd
2012
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3499690/ https://ncbi.nlm.nih.gov/pubmed/22139822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.4421 |
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