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Optimal multistage designs for randomised clinical trials with continuous outcomes

Multistage designs allow considerable reductions in the expected sample size of a trial. When stopping for futility or efficacy is allowed at each stage, the expected sample size under different possible true treatment effects (δ) is of interest. The δ-minimax design is the one for which the maximum...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Wason, James MS, Mander, Adrian P, Thompson, Simon G
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Blackwell Publishing Ltd 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499690/
https://ncbi.nlm.nih.gov/pubmed/22139822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.4421
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