Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations

Drug resistance is an almost inevitable consequence of cancer therapy and ultimately proves fatal for the majority of patients. In many cases, this is the consequence of specific gene mutations that have the potential to be targeted to resensitize the tumor. The ability to uniformly saturate the gen...

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Bibliografiset tiedot
Julkaisussa:Genome Res
Päätekijät: Brammeld, Jonathan S., Petljak, Mia, Martincorena, Inigo, Williams, Steven P., Alonso, Luz Garcia, Dalmases, Alba, Bellosillo, Beatriz, Robles-Espinoza, Carla Daniela, Price, Stacey, Barthorpe, Syd, Tarpey, Patrick, Alifrangis, Constantine, Bignell, Graham, Vidal, Joana, Young, Jamie, Stebbings, Lucy, Beal, Kathryn, Stratton, Michael R., Saez-Rodriguez, Julio, Garnett, Mathew, Montagut, Clara, Iorio, Francesco, McDermott, Ultan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2017
Aiheet:
Method
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378179/
https://ncbi.nlm.nih.gov/pubmed/28179366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.213546.116
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