Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations

Drug resistance is an almost inevitable consequence of cancer therapy and ultimately proves fatal for the majority of patients. In many cases, this is the consequence of specific gene mutations that have the potential to be targeted to resensitize the tumor. The ability to uniformly saturate the gen...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Brammeld, Jonathan S., Petljak, Mia, Martincorena, Inigo, Williams, Steven P., Alonso, Luz Garcia, Dalmases, Alba, Bellosillo, Beatriz, Robles-Espinoza, Carla Daniela, Price, Stacey, Barthorpe, Syd, Tarpey, Patrick, Alifrangis, Constantine, Bignell, Graham, Vidal, Joana, Young, Jamie, Stebbings, Lucy, Beal, Kathryn, Stratton, Michael R., Saez-Rodriguez, Julio, Garnett, Mathew, Montagut, Clara, Iorio, Francesco, McDermott, Ultan
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5378179/
https://ncbi.nlm.nih.gov/pubmed/28179366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.213546.116
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