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Structural heterogeneity of the μ-opioid receptor’s conformational ensemble in the apo state
G-protein coupled receptors (GPCRs) are the largest and most pharmaceutically relevant family of membrane proteins. Here, fully unbiased, enhanced sampling simulations of a constitutively active mutant (CAM) of a class A GPCR, the μ-opioid receptor (μOR), demonstrates repeated transitions between th...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5377942/ https://ncbi.nlm.nih.gov/pubmed/28368046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45761 |
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