Coupling an EML4-ALK centric interactome with RNA interference identifies sensitizers to ALK inhibitors

Patients with lung cancers harboring anaplastic lymphoma kinase (ALK) gene fusions benefit from treatment with ALK kinase inhibitors but acquired resistance inevitably arises. A better understanding of proximal ALK signaling mechanisms may identify sensitizers to ALK inhibitors that disrupt the bala...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Zhang, Guolin, Scarborough, Hannah, Kim, Jihye, Rozhok, Andrii I., Chen, Y. Ann, Zhang, Xiaohui, Song, Lanxi, Bai, Yun, Fang, Bin, Liu, Richard Z., Koomen, John, Tan, Aik Choon, Degregori, James, Haura, Eric B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377910/
https://ncbi.nlm.nih.gov/pubmed/27811184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf5011
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