Coupling an EML4-ALK centric interactome with RNA interference identifies sensitizers to ALK inhibitors

Patients with lung cancers harboring anaplastic lymphoma kinase (ALK) gene fusions benefit from treatment with ALK kinase inhibitors but acquired resistance inevitably arises. A better understanding of proximal ALK signaling mechanisms may identify sensitizers to ALK inhibitors that disrupt the bala...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Zhang, Guolin, Scarborough, Hannah, Kim, Jihye, Rozhok, Andrii I., Chen, Y. Ann, Zhang, Xiaohui, Song, Lanxi, Bai, Yun, Fang, Bin, Liu, Richard Z., Koomen, John, Tan, Aik Choon, Degregori, James, Haura, Eric B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377910/
https://ncbi.nlm.nih.gov/pubmed/27811184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf5011
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