ALK inhibitor response in melanomas expressing EML4-ALK fusions and alternate ALK isoforms

Oncogenic ALK fusions occur in several types of cancer and can be effectively treated with ALK inhibitors; however, ALK fusions and treatment response have not been characterized in malignant melanomas. Recently, a novel isoform of ALK (ALK(ATI)) was reported in 11% of melanomas but the response of...

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Pubblicato in:Mol Cancer Ther
Autori principali: Couts, Kasey L., Bemis, Judson, Turner, Jacqueline A., Bagby, Stacey M., Murphy, Danielle, Christiansen, Jason, Hintzsche, Jennifer D., Le, Anh, Pitts, Todd M., Wells, Keith, Applegate, Allison, Amato, Carol, Multani, Pratik, Chow-Maneval, Edna, Tentler, John J., Shellman, Yiqun G., Rioth, Matthew J., Tan, Aik-Choon, Gonzalez, Rene, Medina, Theresa, Doebele, Robert C., Robinson, William A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752582/
https://ncbi.nlm.nih.gov/pubmed/29054983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0472
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