ALK inhibitor response in melanomas expressing EML4-ALK fusions and alternate ALK isoforms

Oncogenic ALK fusions occur in several types of cancer and can be effectively treated with ALK inhibitors; however, ALK fusions and treatment response have not been characterized in malignant melanomas. Recently, a novel isoform of ALK (ALK(ATI)) was reported in 11% of melanomas but the response of...

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Publicado en:Mol Cancer Ther
Autores principales: Couts, Kasey L., Bemis, Judson, Turner, Jacqueline A., Bagby, Stacey M., Murphy, Danielle, Christiansen, Jason, Hintzsche, Jennifer D., Le, Anh, Pitts, Todd M., Wells, Keith, Applegate, Allison, Amato, Carol, Multani, Pratik, Chow-Maneval, Edna, Tentler, John J., Shellman, Yiqun G., Rioth, Matthew J., Tan, Aik-Choon, Gonzalez, Rene, Medina, Theresa, Doebele, Robert C., Robinson, William A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752582/
https://ncbi.nlm.nih.gov/pubmed/29054983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0472
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