Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function

TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression through RNA processing, in particular, regulation of splicing. Intracellular aggregation of TDP-43 is a hallmark of amyotrophic lateral sclerosis and ubiquitin-positive fro...

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Vydáno v:J Biol Chem
Hlavní autoři: Li, Wen, Reeb, Ashley N., Lin, Binyan, Subramanian, Praveen, Fey, Erin E., Knoverek, Catherine R., French, Rachel L., Bigio, Eileen H., Ayala, Yuna M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377819/
https://ncbi.nlm.nih.gov/pubmed/28167528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753913
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