Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function

TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression through RNA processing, in particular, regulation of splicing. Intracellular aggregation of TDP-43 is a hallmark of amyotrophic lateral sclerosis and ubiquitin-positive fro...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Li, Wen, Reeb, Ashley N., Lin, Binyan, Subramanian, Praveen, Fey, Erin E., Knoverek, Catherine R., French, Rachel L., Bigio, Eileen H., Ayala, Yuna M.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2017
Sujets:
Molecular Bases of Disease
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377819/
https://ncbi.nlm.nih.gov/pubmed/28167528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753913
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