Both Intrinsic Substrate Preference and Network Context Contribute to Substrate Selection of Classical Tyrosine Phosphatases

Reversible tyrosine phosphorylation is a widespread post-translational modification mechanism underlying cell physiology. Thus, understanding the mechanisms responsible for substrate selection by kinases and phosphatases is central to our ability to model signal transduction at a system level. Class...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Palma, Anita, Tinti, Michele, Paoluzi, Serena, Santonico, Elena, Brandt, Bernd Willem, Hooft van Huijsduijnen, Rob, Masch, Antonia, Heringa, Jaap, Schutkowski, Mike, Castagnoli, Luisa, Cesareni, Gianni
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377807/
https://ncbi.nlm.nih.gov/pubmed/28159843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.757518
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