Identification of New Substrates of the Protein-tyrosine Phosphatase PTP1B by Bayesian Integration of Proteome Evidence

There is growing evidence that tyrosine phosphatases display an intrinsic enzymatic preference for the sequence context flanking the target phosphotyrosines. On the other hand, substrate selection in vivo is decisively guided by the enzyme-substrate connectivity in the protein interaction network. W...

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Bibliografiska uppgifter
Huvudupphovsmän: Ferrari, Emanuela, Tinti, Michele, Costa, Stefano, Corallino, Salvatore, Nardozza, Aurelio Pio, Chatraryamontri, Andrew, Ceol, Arnaud, Cesareni, Gianni, Castagnoli, Luisa
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Genomics and Proteomics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039405/
https://ncbi.nlm.nih.gov/pubmed/21123182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.157420
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