Identification of New Substrates of the Protein-tyrosine Phosphatase PTP1B by Bayesian Integration of Proteome Evidence

There is growing evidence that tyrosine phosphatases display an intrinsic enzymatic preference for the sequence context flanking the target phosphotyrosines. On the other hand, substrate selection in vivo is decisively guided by the enzyme-substrate connectivity in the protein interaction network. W...

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Bibliographic Details
Main Authors: Ferrari, Emanuela, Tinti, Michele, Costa, Stefano, Corallino, Salvatore, Nardozza, Aurelio Pio, Chatraryamontri, Andrew, Ceol, Arnaud, Cesareni, Gianni, Castagnoli, Luisa
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Genomics and Proteomics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039405/
https://ncbi.nlm.nih.gov/pubmed/21123182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.157420
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