Identification of New Substrates of the Protein-tyrosine Phosphatase PTP1B by Bayesian Integration of Proteome Evidence

There is growing evidence that tyrosine phosphatases display an intrinsic enzymatic preference for the sequence context flanking the target phosphotyrosines. On the other hand, substrate selection in vivo is decisively guided by the enzyme-substrate connectivity in the protein interaction network. W...

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Detalhes bibliográficos
Main Authors: Ferrari, Emanuela, Tinti, Michele, Costa, Stefano, Corallino, Salvatore, Nardozza, Aurelio Pio, Chatraryamontri, Andrew, Ceol, Arnaud, Cesareni, Gianni, Castagnoli, Luisa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Genomics and Proteomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3039405/
https://ncbi.nlm.nih.gov/pubmed/21123182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.157420
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