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The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities

The activity of protein tyrosine phosphatases (PTPs) is restricted by their substrate specificities. The analysis of PTP specificity was greatly helped by the discovery that "substrate-trapping" PTP mutants, such as PTP-1B D181A, stably and specifically bind their substrates. We have set u...

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Bibliografski detalji
Glavni autori: Espanel, Xavier, Huguenin-Reggiani, Martine, van Huijsduijnen, Rob Hooft
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2002
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373693/
https://ncbi.nlm.nih.gov/pubmed/12237455
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