Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation

BACKGROUND: PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on immune response is still controversial. PTPH1 dephosphorylates TCRzeta in vitro, inhibiting the downstream inflammatory signaling pathway, however no immunological phenotype has been detected in primary T cell...

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Bibliografiske detaljer
Main Authors: Patrignani, Claudia, Lafont, David T, Muzio, Valeria, Gréco, Béatrice, van Huijsduijnen, Rob Hooft, Zaratin, Paola F
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873500/
https://ncbi.nlm.nih.gov/pubmed/20353590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-7-16
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