Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB

Tyrosine kinases and phosphatases establish the crucial balance of tyrosine phosphorylation in cellular signaling, but creating specific inhibitors of protein Tyr phosphatases (PTPs) remains a challenge. Here we report the development of a potent, selective inhibitor of Mycobacterium tuberculosis Pt...

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Detalhes bibliográficos
Main Authors: Grundner, Christoph, Perrin, Dominique, van Huijsduijnen, Rob Hooft, Swinnen, Dominique, Gonzalez, Jérome, Gee, Christine L., Wells, Timothy N., Alber, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775457/
https://ncbi.nlm.nih.gov/pubmed/17437721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.03.003
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