Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB

Tyrosine kinases and phosphatases establish the crucial balance of tyrosine phosphorylation in cellular signaling, but creating specific inhibitors of protein Tyr phosphatases (PTPs) remains a challenge. Here we report the development of a potent, selective inhibitor of Mycobacterium tuberculosis Pt...

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Hlavní autoři: Grundner, Christoph, Perrin, Dominique, van Huijsduijnen, Rob Hooft, Swinnen, Dominique, Gonzalez, Jérome, Gee, Christine L., Wells, Timothy N., Alber, Tom
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775457/
https://ncbi.nlm.nih.gov/pubmed/17437721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.03.003
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