Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB

Tyrosine kinases and phosphatases establish the crucial balance of tyrosine phosphorylation in cellular signaling, but creating specific inhibitors of protein Tyr phosphatases (PTPs) remains a challenge. Here we report the development of a potent, selective inhibitor of Mycobacterium tuberculosis Pt...

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Bibliografiset tiedot
Päätekijät: Grundner, Christoph, Perrin, Dominique, van Huijsduijnen, Rob Hooft, Swinnen, Dominique, Gonzalez, Jérome, Gee, Christine L., Wells, Timothy N., Alber, Tom
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2007
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775457/
https://ncbi.nlm.nih.gov/pubmed/17437721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.03.003
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