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Design and Synthesis of Nonpeptidic, Small Molecule Inhibitors for the Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB
The design and synthesis of new inhibitor analogues for the Mycobacterium tuberculosis (Mtb) phosphatase PtpB is described. Analogues were synthesized by incorporation of two common and effective phosphate mimetics, the isothiazolidinone (IZD) and the difluoromethylphosphonic acid (DFMP). The basic...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3009555/ https://ncbi.nlm.nih.gov/pubmed/20644889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0ob00182a |
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