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A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer
Dihydrofolate reductase (DHFR) plays a key role in folate metabolism and is a target molecule of methotrexate. An increase in the cellular expression level of DHFR is one of the mechanisms of tumor resistance to methotrexate. The present study investigated the possibility that adenosine-to-inosine R...
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| 發表在: | J Biol Chem |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5377802/ https://ncbi.nlm.nih.gov/pubmed/28188287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775684 |
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