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A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer
Dihydrofolate reductase (DHFR) plays a key role in folate metabolism and is a target molecule of methotrexate. An increase in the cellular expression level of DHFR is one of the mechanisms of tumor resistance to methotrexate. The present study investigated the possibility that adenosine-to-inosine R...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5377802/ https://ncbi.nlm.nih.gov/pubmed/28188287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.775684 |
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