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Identification of 4-(3-Pyridyl)-4-oxobutyl-2′-deoxycytidine Adducts Formed in the Reaction of DNA with 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone: A Chemically Activated Form of Tobacco-Specific Carcinogens
[Image: see text] Metabolic activation of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) and N′-nitrosonornicotine (NNN, 2) results in the formation of 4-(3-pyridyl)-4-oxobutyl (POB)-DNA adducts, several of which have been previously identified...
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| Publicat a: | ACS Omega |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical Society
2017
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5377278/ https://ncbi.nlm.nih.gov/pubmed/28393135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.7b00072 |
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