Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats

Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Ra...

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Bibliografiske detaljer
Udgivet i:Oxid Med Cell Longev
Main Authors: Luck, Christian, DeMarco, Vincent G., Mahmood, Abuzar, Gavini, Madhavi P., Pulakat, Lakshmi
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376943/
https://ncbi.nlm.nih.gov/pubmed/28408970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5724046
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