Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats

Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Ra...

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發表在:Oxid Med Cell Longev
Main Authors: Luck, Christian, DeMarco, Vincent G., Mahmood, Abuzar, Gavini, Madhavi P., Pulakat, Lakshmi
格式: Artigo
語言:Inglês
出版: Hindawi 2017
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376943/
https://ncbi.nlm.nih.gov/pubmed/28408970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5724046
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