Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats

Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Ra...

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Dades bibliogràfiques
Publicat a:Oxid Med Cell Longev
Autors principals: Luck, Christian, DeMarco, Vincent G., Mahmood, Abuzar, Gavini, Madhavi P., Pulakat, Lakshmi
Format: Artigo
Idioma:Inglês
Publicat: Hindawi 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376943/
https://ncbi.nlm.nih.gov/pubmed/28408970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5724046
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