Differential Regulation of Cardiac Function and Intracardiac Cytokines by Rapamycin in Healthy and Diabetic Rats

Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Ra...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Luck, Christian, DeMarco, Vincent G., Mahmood, Abuzar, Gavini, Madhavi P., Pulakat, Lakshmi
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376943/
https://ncbi.nlm.nih.gov/pubmed/28408970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5724046
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