p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex

Activation of the stress-responsive transcription factor NRF2 is the major line of defense to combat oxidative or electrophilic insults. Under basal conditions, NRF2 is continuously ubiquitylated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and is targeted to the proteasome for degradation (th...

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Gepubliceerd in:Mol Cell Biol
Hoofdauteurs: Tao, Shasha, Liu, Pengfei, Luo, Gang, Rojo de la Vega, Montserrat, Chen, Heping, Wu, Tongde, Tillotson, Joseph, Chapman, Eli, Zhang, Donna D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376629/
https://ncbi.nlm.nih.gov/pubmed/28115426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00660-16
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