HIV-Specific Granzyme B-Secreting but Not Gamma Interferon-Secreting T Cells Are Associated with Reduced Viral Reservoirs in Early HIV Infection

A major barrier to a human immunodeficiency virus type 1 (HIV-1) infection cure is the establishment of a viral reservoir in spite of combined antiretroviral therapy (cART). It is unclear how HIV-specific cytotoxic T lymphocytes (CTLs) influence the size of the reservoir in early HIV infection. Twen...

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Bibliographic Details
Published in:J Virol
Main Authors: Yue, Feng Yun, Cohen, Jared C., Ho, Mu, Rahman, A. K. M. Nur-ur, Liu, Jun, Mujib, Shariq, Saiyed, Aamir, Hundal, Sabrina, Khozin, Alexandra, Bonner, Phil, Liu, Daheng, Benko, Erika, Kovacs, Colin, Ostrowski, Mario
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5375660/
https://ncbi.nlm.nih.gov/pubmed/28179527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02233-16
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