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The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease
Rosenthal fibers (RFs) are cytoplasmic, proteinaceous aggregates. They are the pathognomonic feature of the astrocyte pathology in Alexander Disease (AxD), a neurodegenerative disorder caused by heterozygous mutations in the GFAP gene, encoding glial fibrillary acidic protein (GFAP). Although RFs ha...
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| Veröffentlicht in: | Acta Neuropathol Commun |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5374671/ https://ncbi.nlm.nih.gov/pubmed/28359321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0425-9 |
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