Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism

BACKGROUND: Recent investigations suggest role(s) of human arylamine N-acetyltransferase 1 (NAT1) in breast cancer. Rat NAT2 is orthologous to human NAT1 and the gene products are functional homologs. We conducted in vivo studies using F344.WKY-Nat2 (rapid/slow) rats, congenic at rat Nat2 for high (...

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Pubblicato in:BMC Cancer
Autori principali: Stepp, Marcus W., Doll, Mark A., Samuelson, David J., Sanders, Mary Ann G., States, J. Christopher, Hein, David W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374573/
https://ncbi.nlm.nih.gov/pubmed/28359264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3221-9
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