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Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection

Widespread gene transfer to the retina is challenging as it requires vector systems to overcome physical and biochemical barriers to enter and diffuse throughout retinal tissue. We investigated whether exosome-associated adeno-associated virus, (exo-AAV) enabled broad retinal targeting following int...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Wassmer, Sarah J., Carvalho, Livia S., György, Bence, Vandenberghe, Luk H., Maguire, Casey A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374486/
https://ncbi.nlm.nih.gov/pubmed/28361998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45329
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