Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice

Surgery can induce cognitive decline, a risk that increases with advancing age. In rodents, postoperative cognitive decline (POCD) is associated with the inflammatory activation of hippocampal microglia. To examine the role of microglia in POCD, we inhibited the colony-stimulating factor 1 receptor...

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Bibliographische Detailangaben
Veröffentlicht in:JCI Insight
Hauptverfasser: Feng, Xiaomei, Valdearcos, Martin, Uchida, Yosuke, Lutrin, David, Maze, Mervyn, Koliwad, Suneil K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374063/
https://ncbi.nlm.nih.gov/pubmed/28405620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91229
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