Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice

BACKGROUND: Postoperative cognitive decline (PCD) requires microglial activation. Voltage-gated Kv1.3 potassium channels are involved in microglial activation. We determined the role of Kv1.3 in PCD and the efficacy and safety of inhibiting Kv1.3 with phenoxyalkoxypsoralen-1 (PAP-1) in preventing PC...

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Vydáno v:Br J Anaesth
Hlavní autoři: Lai, Ieng K., Valdearcos, Martin, Morioka, Kazuhito, Saxena, Sarah, Feng, Xiaomei, Li, Rong, Uchida, Yosuke, Lijun, An, Li, Wei, Pan, Jonathan, Koliwad, Suneil, Marcucio, Ralph, Wulff, Heike, Maze, Mervyn
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
Témata:
Laboratory Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497028/
https://ncbi.nlm.nih.gov/pubmed/32624183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2020.05.018
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