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Dexmedetomidine prevents cognitive decline by enhancing resolution of HMGB1-induced inflammation through a vagomimetic action in mice
BACKGROUND: Inflammation initiated by damage-associated molecular patterns has been implicated for the cognitive decline associated with surgical trauma and serious illness. We determined whether resolution of inflammation mediates dexmedetomidine-induced reduction of damage-associated molecular pat...
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| Pubblicato in: | Anesthesiology |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6445386/ https://ncbi.nlm.nih.gov/pubmed/29252509 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002038 |
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