Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine

Extensive 3′ alternative splicing of the mu opioid receptor gene OPRM1 creates multiple C-terminal splice variants. However, their behavioral relevance remains unknown. The present study generated 3 mutant mouse models with truncated C termini in 2 different mouse strains, C57BL/6J (B6) and 129/SvEv...

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Publicado en:J Clin Invest
Autores principales: Xu, Jin, Lu, Zhigang, Narayan, Ankita, Le Rouzic, Valerie P., Xu, Mingming, Hunkele, Amanda, Brown, Taylor G., Hoefer, William F., Rossi, Grace C., Rice, Richard C., Martínez-Rivera, Arlene, Rajadhyaksha, Anjali M., Cartegni, Luca, Bassoni, Daniel L., Pasternak, Gavril W., Pan, Ying-Xian
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373896/
https://ncbi.nlm.nih.gov/pubmed/28319053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88760
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