Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis

Tissue fibrosis is the primary cause of long-term graft failure after organ transplantation. In lung allografts, progressive terminal airway fibrosis leads to an irreversible decline in lung function termed bronchiolitis obliterans syndrome (BOS). Here, we have identified an autocrine pathway linkin...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Cao, Pengxiu, Aoki, Yoshiro, Badri, Linda, Walker, Natalie M., Manning, Casey M., Lagstein, Amir, Fearon, Eric R., Lama, Vibha N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373892/
https://ncbi.nlm.nih.gov/pubmed/28240604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88896
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