Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis

Tissue fibrosis is the primary cause of long-term graft failure after organ transplantation. In lung allografts, progressive terminal airway fibrosis leads to an irreversible decline in lung function termed bronchiolitis obliterans syndrome (BOS). Here, we have identified an autocrine pathway linkin...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Cao, Pengxiu, Aoki, Yoshiro, Badri, Linda, Walker, Natalie M., Manning, Casey M., Lagstein, Amir, Fearon, Eric R., Lama, Vibha N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373892/
https://ncbi.nlm.nih.gov/pubmed/28240604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88896
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