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Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons
Ribonucleoprotein (RNP) granules are enriched in specific RNAs and RNA-binding proteins (RBPs) and mediate critical cellular processes. Purified RBPs form liquid droplets in vitro through liquid–liquid phase separation and liquid-like non–membrane-bound structures in cells. Mutations in the human RB...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5373408/ https://ncbi.nlm.nih.gov/pubmed/28265061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614462114 |
| Oznake: |
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