Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

In the adenoma-carcinoma sequence, it is proposed that intestinal polyps evolve through a set of defined mutations toward metastatic colorectal cancer (CRC). Here, we dissect this adenoma-carcinoma sequence in vivo by using an orthotopic organoid transplantation model of human colon organoids engine...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Fumagalli, Arianna, Drost, Jarno, Suijkerbuijk, Saskia J. E., van Boxtel, Ruben, de Ligt, Joep, Offerhaus, G. Johan, Begthel, Harry, Beerling, Evelyne, Tan, Ee Hong, Sansom, Owen J., Cuppen, Edwin, Clevers, Hans, van Rheenen, Jacco
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373343/
https://ncbi.nlm.nih.gov/pubmed/28270604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701219114
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