Active elimination of intestinal cells drives oncogenic growth in organoids

Competitive cell interactions play a crucial role in quality control during development and homeostasis. Here, we show that cancer cells use such interactions to actively eliminate wild-type intestine cells in enteroid monolayers and organoids. This apoptosis-dependent process boosts proliferation o...

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Pubblicato in:Cell Rep
Autori principali: Krotenberg Garcia, Ana, Fumagalli, Arianna, Le, Huy Quang, Jackstadt, Rene, Lannagan, Tamsin Rosemary Margaret, Sansom, Owen James, van Rheenen, Jacco, Suijkerbuijk, Saskia Jacoba Elisabeth
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8278394/
https://ncbi.nlm.nih.gov/pubmed/34233177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109307
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