Sepiapterin reductase gene‐disrupted mice suffer from hypertension with fluctuation and bradycardia

(6R)‐l‐erythro‐5,6,7,8‐Tetrahydrobiopterin (BH4) is an essential cofactor for monoamine and nitric oxide (NO) production. Sepiapterin reductase (SPR) catalyzes the final step in BH4 biosynthesis. We analyzed the cardiovascular function of adult Spr gene‐disrupted (Spr (−/−)) mice for the first time....

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: Sumi‐Ichinose, Chiho, Suganuma, Yui, Kano, Taiki, Ihira, Noriko, Nomura, Hiroko, Ikemoto, Kazuhisa, Hata, Tadayoshi, Katoh, Setsuko, Ichinose, Hiroshi, Kondo, Kazunao
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5371564/
https://ncbi.nlm.nih.gov/pubmed/28320892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13196
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