Sulfa Drugs Inhibit Sepiapterin Reduction and Chemical Redox Cycling by Sepiapterin Reductase

Sepiapterin reductase (SPR) catalyzes the reduction of sepiapterin to dihydrobiopterin (BH2), the precursor for tetrahydrobiopterin (BH4), a cofactor critical for nitric oxide biosynthesis and alkylglycerol and aromatic amino acid metabolism. SPR also mediates chemical redox cycling, catalyzing one-...

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Bibliografiske detaljer
Udgivet i:J Pharmacol Exp Ther
Main Authors: Yang, Shaojun, Jan, Yi-Hua, Mishin, Vladimir, Richardson, Jason R., Hossain, Muhammad M., Heindel, Ned D., Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2015
Fag:
Toxicology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352594/
https://ncbi.nlm.nih.gov/pubmed/25550200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.221572
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