Sepiapterin Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells

In the lung, chemical redox cycling generates highly toxic reactive oxygen species that can cause alveolar inflammation and damage to the epithelium, as well as fibrosis. In this study, we identified a cytosolic NADPH-dependent redox cycling activity in mouse lung epithelial cells as sepiapterin red...

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Главные авторы: Yang, Shaojun, Jan, Yi-Hua, Gray, Joshua P., Mishin, Vladimir, Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
Предметы:
Enzymology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696693/
https://ncbi.nlm.nih.gov/pubmed/23640889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.402164
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