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Diacetyl/L-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells

Reactive carbonyls such as diacetyl (2,3-butanedione) and 2,3-pentanedione in tobacco and many food and consumer products are known to cause severe respiratory diseases. Many of these chemicals are detoxified by carbonyl reductases in the lung, in particular, dicarbonyl/L-xylulose reductase (DCXR),...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Yang, Shaojun, Jan, Yi-Hua, Mishin, Vladimir, Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708134/
https://ncbi.nlm.nih.gov/pubmed/28595002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00052
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