Partial Biopterin Deficiency Disturbs Postnatal Development of the Dopaminergic System in the Brain

Postnatal development of dopaminergic system is closely related to the development of psychomotor function. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of dopamine and requires tetrahydrobiopterin (BH4) as a cofactor. To clarify the effect of partial BH4 deficiency on p...

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Autors principals: Homma, Daigo, Sumi-Ichinose, Chiho, Tokuoka, Hirofumi, Ikemoto, Kazuhisa, Nomura, Takahide, Kondo, Kazunao, Katoh, Setsuko, Ichinose, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020753/
https://ncbi.nlm.nih.gov/pubmed/21062748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.159426
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