Partial Biopterin Deficiency Disturbs Postnatal Development of the Dopaminergic System in the Brain

Postnatal development of dopaminergic system is closely related to the development of psychomotor function. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of dopamine and requires tetrahydrobiopterin (BH4) as a cofactor. To clarify the effect of partial BH4 deficiency on p...

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Detalhes bibliográficos
Main Authors: Homma, Daigo, Sumi-Ichinose, Chiho, Tokuoka, Hirofumi, Ikemoto, Kazuhisa, Nomura, Takahide, Kondo, Kazunao, Katoh, Setsuko, Ichinose, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020753/
https://ncbi.nlm.nih.gov/pubmed/21062748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.159426
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